How does Simparica work?

Simparica for dogs provides fast relief from parasites and the diseases they carry in one tasty treat, making pest protection no hassle for you and your pet.

Simparica is the once-a-month flea and tick treatment proven to kill parasites fast. Available in a tasty treat that dogs love, each soft chew provides up to 35 days of protection, arming your dog against biting pests and the diseases they can carry.

Like other oral flea and tick treatments, Simparicafor dogs works by entering your pet’s bloodstream immediately after ingestion. When a flea or tick bites, it is exposed to the formula’s FDA-approved active ingredient, sarolaner, which attacks and kills parasites fast. Within just three hours, Simparica effectively begins killing fleas and, after 8 hours, starts to kill ticks including the lone star tick, black-legged tick, brown dog tick, American dog tick, and Gulf Coast tick. Simparica has also been proven effective in relieving and preventing ear mites and mange. The long-lasting formula continues to control parasites for up to 35 days, providing continued relief from parasites and the diseases they carry.

Simparica’s powerful ingredient sarolaner is an insecticide and acaricide that affects nerve cell function in invertebrates. It works by altering gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. GAGA-gated channels help dampen nerve transmissions, which sarolaner disrupts to create an influx of transmissions in fleas and ticks. At the same time, the compound opens glutamate-gated channels, contributing to the flood of nerve transmissions. The resulting seizures are fatal to fleas and ticks, but because sarolaneris more effective on invertebrates than mammals, Simparica has been found proven safe for dogs during field trials.

While adverse reactions were rarely seen, the most common side effects during a three-month field trial included vomiting, decreased appetite, weakness, lethargy, and softened stools. Though most reactions related to Fido’s digestive system, in a few isolated cases, dogs showed more serious side effects such as tremors, muscle twitching, and seizures. Simparica is available by prescription only, so be sure to discuss any history of seizure disorders with your veterinarian when discussing the best flea and tick treatment for your pet.

Simparica is safe for dogs as young as 6 months old and weighing at least 2.8 pounds. The chewable tablets are available in doses for dogs of every size and, because Simparica is delivered orally, there’s no messy application or need to wait before bathing your pet. The treatment has not been evaluated for use in pregnant, breeding or lactating dogs, so these pets will need alternative flea and tick prevention. Talk to your vet about Simparica to provide your dog with safe, effective relief from biting parasites with one tasty, monthly treat.